Investigating how cholesterol affects cell growth regulation
Lysosomal cholesterol-dependent anabolic regulation
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11021084
This study is looking at how cholesterol affects a protein that helps control cell growth and metabolism, which could lead to new insights for managing conditions like obesity, diabetes, and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11021084 on ClinicalTrials.gov |
What this research studies
This research explores the role of cholesterol in regulating mTORC1, a key protein complex that controls cell growth and metabolism. By examining how cholesterol interacts with cellular signals, the study aims to uncover new mechanisms that could influence conditions like obesity, diabetes, and cancer. The research involves detailed biochemical analyses and cellular experiments to understand how cholesterol impacts the activation of mTORC1 and its downstream effects on cell growth and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are affected by metabolic disorders, obesity, or related health issues.
Not a fit: Patients with conditions unrelated to metabolic regulation or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing obesity, diabetes, and cancer by targeting cholesterol's role in cell growth regulation.
How similar studies have performed: Previous studies have shown promising results in understanding the role of metabolic signals in cell growth, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INOKI, KEN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: INOKI, KEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.