Investigating how cholecystokinin affects memory-related brain cells in Alzheimer's disease
Role of Cholecystokinin in the Dentate Gyrus
This study is looking at how a brain chemical called cholecystokinin (CCK) affects the growth of new brain cells and memory, especially in people with Alzheimer's disease, to find ways to help improve brain health and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11124595 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cholecystokinin (CCK) in the dentate gyrus of the brain, particularly in relation to adult neurogenesis and memory function. By studying both healthy and Alzheimer's disease models, the research aims to identify how CCK influences the environment that supports the growth of new brain cells. The approach involves stimulating specific brain cells to see if increasing CCK levels can enhance the proliferation of neural stem cells and improve memory-related functions. This could lead to new strategies for promoting brain repair in individuals with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease.
Not a fit: Patients with other forms of dementia or neurological conditions unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance memory and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in understanding neurogenesis and memory function, but the specific role of CCK in this context is still being explored, making this research both relevant and novel.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Song, Juan — Univ of North Carolina Chapel Hill
- Study coordinator: Song, Juan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.