Investigating how chlorine and bromine gases cause lung injury
Halolipid-Neutrophil Extracellular Trap Axis in Halogen Lung Injury
This study is looking into how exposure to chlorine and bromine gases can harm your lungs, especially during accidents or attacks, and aims to find ways to help protect and heal lung health by understanding what happens in the body after such exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10891619 on NIH RePORTER |
What this research studies
This research focuses on understanding the harmful effects of chlorine and bromine gas exposure, which can occur during industrial accidents or chemical warfare. The study aims to uncover the mechanisms by which these gases lead to lung injury, particularly through the formation of neutrophil extracellular traps (NETs) that contribute to coagulopathy and organ damage. By examining the biochemical changes in the lungs and circulation after exposure, the researchers hope to identify potential therapeutic targets to mitigate these injuries. The research involves both animal models and biochemical analyses to explore the relationship between gas exposure and lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to chlorine or bromine gases, particularly in industrial or military settings.
Not a fit: Patients who have not been exposed to chlorine or bromine gases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect against lung injuries caused by chlorine and bromine gas exposure.
How similar studies have performed: While the specific mechanisms of chlorine and bromine gas toxicity are being explored in this research, similar studies have shown success in understanding gas-related lung injuries, indicating a promising avenue for therapeutic development.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ford, David a. — Saint Louis University
- Study coordinator: Ford, David a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.