Investigating how chloride levels in cell organelles affect health and disease
Official title: Development and Application of Organelle Chemotype Fingerprinting for the Functional Investigation of Organellar Chloride
Funded at Clarkson University · NIH-11101310 · Data updated 2026-11-12
This study is looking at how chloride ions work inside our cells and how problems with them can lead to conditions like cystic fibrosis, with the goal of finding new ways to help treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clarkson University NIH-funded |
| Lab location | 1 site (Potsdam, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $361,614 |
| NIH project number | 5R35GM147112-04 |
| Project ID | NIH-11101310 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cystic fibrosis or other conditions related to chloride channel dysregulation.
✕Less likely to help
Patients without any chloride channel-related disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of chloride ions within cell organelles and how their dysregulation can lead to diseases like cystic fibrosis. By developing advanced techniques to measure chloride levels in live cells, the study aims to uncover the physiological functions of organellar chloride and its implications for health. The research will utilize innovative organelle chemotype fingerprinting methods to analyze chloride channels, which are currently underexplored compared to other ion channels. This approach could pave the way for new therapeutic strategies targeting organellar chloride channels.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for diseases associated with chloride channel dysfunction, improving patient outcomes.
How similar studies have gone: While there have been successful studies on plasma membrane chloride channels, this research is pioneering in its focus on organellar chloride channels, making it a novel approach.
Where this research is happening
-
Clarkson University
Potsdam, United States Active
Researchers
- Principal investigator: Leung, Ka Ho — Clarkson University
- Study coordinator: Leung, Ka Ho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.