Investigating how chloride channels in blood vessel cells affect blood flow and pressure
Chloride channels in endothelial cells
This study is looking at how certain channels in the cells that line our blood vessels work and what happens to them when someone has high blood pressure, with the hope of finding new ways to help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11026359 on NIH RePORTER |
What this research studies
This research focuses on endothelial cells, which line blood vessels and play a crucial role in regulating blood flow and blood pressure. The study aims to understand how chloride channels, specifically TMEM16A, function in these cells and how they may become dysfunctional in conditions like hypertension. By using advanced techniques, including genetically modified mice, the researchers will explore the signaling pathways that activate these channels and their impact on vascular health. This could lead to new insights into cardiovascular diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular conditions, particularly those experiencing hypertension.
Not a fit: Patients with non-cardiovascular conditions or those without any vascular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiovascular diseases by improving our understanding of blood vessel function.
How similar studies have performed: While the specific focus on TMEM16A channels in endothelial cells is relatively novel, similar research has shown promise in understanding vascular function and disease mechanisms.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Jaggar, Jonathan H — University of Tennessee Health Sci Ctr
- Study coordinator: Jaggar, Jonathan H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.