Investigating how Chibby proteins affect male fertility and sperm development
Official title: The Role of Chibby Family Members in Spermatogenesis and Male Fertility
Funded at State University New York Stony Brook · NIH-11021025 · Data updated 2026-11-12
This study is looking at how certain proteins help sperm develop and move properly, which could help us understand and treat male infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | May 24, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $426,265 |
| NIH project number | 5R01HD109232-03 |
| Project ID | NIH-11021025 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing infertility issues related to sperm motility or structural abnormalities.
✕Less likely to help
Patients with infertility not related to sperm motility or structural issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of Chibby family proteins in the development of sperm and their impact on male fertility. The study examines how these proteins contribute to the formation and function of cilia, which are essential for sperm motility. By exploring the molecular interactions and mechanisms involved in sperm flagellum development, the research aims to uncover potential causes of male infertility linked to abnormal sperm structure. Patients may benefit from insights that could lead to new treatments for infertility issues.
Why it matters
Potential benefit: If successful, this research could provide new avenues for treating male infertility caused by abnormal sperm development.
How similar studies have gone: Previous research has shown promising results in understanding the role of ciliary proteins in fertility, indicating that this approach may yield valuable insights.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Takemaru, Ken-Ichi — State University New York Stony Brook
- Study coordinator: Takemaru, Ken-Ichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.