Investigating how chemotherapy affects ovarian cancer spread
Chemotherapy induced MASP activation and ovarian cancer metastasis
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11127928
This study is looking at how chemotherapy might sometimes make high-grade serous ovarian cancer spread more quickly, and it aims to find new ways to help prevent this from happening, so patients can have better treatment outcomes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11127928 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how chemotherapy can inadvertently promote the spread of high-grade serous ovarian cancer (HGSOC) after treatment. It examines the mechanisms by which cancer cells may evolve and become more aggressive during chemotherapy, leading to metastasis. The study aims to identify potential new therapies that could prevent or reduce this metastatic process, ultimately improving outcomes for patients with ovarian cancer. By analyzing tumor behavior and responses to treatment, the research seeks to develop strategies that could enhance the effectiveness of existing therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with high-grade serous ovarian cancer who are undergoing or have undergone chemotherapy.
Not a fit: Patients with early-stage ovarian cancer who have not yet received chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that reduce the risk of metastasis in ovarian cancer patients, potentially increasing survival rates.
How similar studies have performed: Previous research has indicated that chemotherapy can have unintended effects on cancer metastasis, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANTALIS, TONI M — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: ANTALIS, TONI M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, anti-cancer drug