Investigating how chemotherapy affects breast cancer spread and immune function in the liver
Understanding the impact of chemotherapy on breast cancer metastasis and immune function in the liver
This study is looking at how chemotherapy affects the immune system and the spread of triple-negative breast cancer, with the hope of finding out how these treatments might change the way new immune therapies work for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10923796 on NIH RePORTER |
What this research studies
This research explores the effects of chemotherapy on breast cancer, particularly focusing on triple-negative breast cancer (TNBC). It examines how standard treatments, including anthracycline-cyclophosphamide and taxane-based chemotherapy, impact the immune system and the spread of cancer to the liver. By using mouse models and clinical samples, the study aims to understand the relationship between chemotherapy, immune function, and tumor behavior in metastatic environments. The goal is to identify how chemotherapy may impair immune responses, potentially affecting the effectiveness of new immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage triple-negative breast cancer who are undergoing or have undergone chemotherapy.
Not a fit: Patients with non-breast cancer types or those who are not receiving chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance the effectiveness of chemotherapy and immunotherapy for breast cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding the immune response to chemotherapy, but this specific investigation into liver metastasis in TNBC is relatively novel.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mcallister, Sandra S — Brigham and Women's Hospital
- Study coordinator: Mcallister, Sandra S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.