Investigating how chemical modifications affect gene regulation in human cells
Official title: Chemical strategies to investigate biochemical crosstalk in human chromatin
Funded at University of Washington · NIH-11074037 · Data updated 2026-11-12
This study is looking at how changes in certain proteins can affect the way our genes work, especially focusing on a protein called p53 that helps prevent cancer, and it’s aimed at anyone interested in understanding how our cells stay healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $365,604 |
| NIH project number | 5R35GM149228-03 |
| Project ID | NIH-11074037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene regulation, particularly those involving the p53 protein, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those not involving the p53 protein may not benefit from this research.
What this research studies
This research focuses on understanding the complex interactions within chromatin, the structure that organizes our genetic material. By using advanced chemical techniques, the study aims to create modified proteins that mimic natural processes, particularly those involving the tumor suppressor protein p53. Through a series of biochemical and biophysical tests, the researchers will explore how specific modifications influence gene expression and chromatin function. This could lead to new insights into the regulation of genes that are crucial for maintaining cellular health.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation, potentially leading to new therapeutic strategies for diseases related to gene expression, including cancer.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through biochemical modifications, indicating that this approach has potential for success.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Chatterjee, Champak — University of Washington
- Study coordinator: Chatterjee, Champak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.