Investigating how changes in timing affect brain development.
Official title: Long-term neural consequences of altered critical period timing.
Funded at Washington University · NIH-11072530 · Data updated 2026-11-12
This study is looking at how different stages of brain development affect how brain cells connect and work together, especially focusing on a type of support cell called astrocytes, to help us understand how these changes might influence behavior and brain function.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 24, 2025 |
| Project end | January 23, 2028 |
| Funding year | 2024 |
| Award (this year) | $83,328 |
| NIH project number | 1F32MH139159-01 |
| Project ID | NIH-11072530 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with autism spectrum disorder or related developmental conditions.
✕Less likely to help
Patients with fully developed neural circuits and no history of developmental disorders may not receive benefit from this research.
What this research studies
This research explores how the timing of critical periods in brain development influences the formation and function of neural circuits. By studying animal models, particularly focusing on astrocytes and their role in signaling, the research aims to understand how these signals affect the wiring of neural circuits during crucial developmental windows. The methodology includes genetic screening and manipulation of astrocyte signaling to observe changes in critical period dynamics and their impact on behavior and neural function.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the timing of brain development, potentially informing interventions for conditions like autism spectrum disorder.
How similar studies have gone: Previous research has shown promising results in understanding critical periods and their regulation, indicating that this approach has potential for significant findings.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Postolache, Maggie — Washington University
- Study coordinator: Postolache, Maggie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.