Investigating how changes in the tumor environment affect glioblastoma behavior
Official title: The Role of HA Remodeling and Mesenchymal Transitions in Glioblastoma
Funded at University of Louisville · NIH-10796006 · Data updated 2026-11-12
This study is looking at how the environment around glioblastoma tumors affects their growth and behavior, with the hope of finding new ways to create better treatments for patients battling this tough brain cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $469,500 |
| NIH project number | 1R15CA274344-01A1 |
| Project ID | NIH-10796006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, a highly aggressive brain cancer with poor treatment outcomes. It aims to understand how the tumor microenvironment, particularly changes in biophysical properties like matrix stiffness and composition, influences the behavior of glioblastoma cells. By studying the role of hyaluronic acid remodeling and mesenchymal transitions, the research seeks to identify new therapeutic targets that could improve treatment effectiveness. Patients may benefit from insights that lead to more tailored and effective therapies for glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that significantly improve outcomes for glioblastoma patients.
How similar studies have gone: While the specific approach of targeting biophysical cues in glioblastoma is relatively novel, similar strategies in other cancers have shown promising results.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Chen, Joseph — University of Louisville
- Study coordinator: Chen, Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.