Investigating how changes in the fallopian tube may lead to ovarian cancer
Precancer Niche Formation in the Fallopian Tube
['FUNDING_OTHER'] · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · NIH-11059038
This study is looking at how changes in the fallopian tubes might lead to ovarian cancer in women with BRCA1 mutations, and it hopes to find early signs that could help catch the cancer sooner.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA GREATER LOS ANGELES HEALTHCARE SYSTEM (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11059038 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the early changes in the fallopian tube that can lead to ovarian cancer, particularly in women with BRCA1 mutations. It examines the cellular environment and the transformation of secretory and ciliated cells, which may contribute to the development of precancerous lesions. By analyzing tissue samples from both mutation carriers and non-carriers, the study aims to identify specific biomarkers that could help in early detection of ovarian cancer. The approach includes histological and molecular analyses to uncover the mechanisms behind these cellular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research include women with BRCA1 mutations or those at high risk for ovarian cancer.
Not a fit: Patients without a genetic predisposition to ovarian cancer or those who do not have any risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of early detection methods for ovarian cancer, improving outcomes for patients.
How similar studies have performed: While the specific focus on fallopian tube changes in relation to ovarian cancer is novel, similar research has shown promise in identifying biomarkers for other cancers.
Where this research is happening
LOS ANGELES, UNITED STATES
- VA GREATER LOS ANGELES HEALTHCARE SYSTEM — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORSULIC, SANDRA — VA GREATER LOS ANGELES HEALTHCARE SYSTEM
- Study coordinator: ORSULIC, SANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.