Investigating how changes in specific genes affect cancer development
Tumor suppressor vulnerability conferred by aneuploid loss of haploinsufficient metallothionein genes
This study is looking at how having the wrong number of chromosomes can affect cancer growth and hopes to find new ways to treat cancer by exploring specific genes and pathways, which could help doctors provide better, more personalized care for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10469891 on NIH RePORTER |
What this research studies
This research focuses on understanding how aneuploidy, or the abnormal number of chromosomes, influences cancer progression by affecting specific genetic pathways. The team utilizes advanced bioinformatics tools to identify which pathways are disrupted in various cancers, particularly looking at the cadmium response pathway and metallothionein genes. By studying these genetic changes, the research aims to uncover new therapeutic targets that could lead to more effective cancer treatments. Patients may benefit from insights that could improve precision oncology approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with high-grade serous ovarian cancer or other malignancies associated with aneuploidy.
Not a fit: Patients with cancers that do not exhibit aneuploidy or are not related to the cadmium response pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by identifying new therapeutic targets.
How similar studies have performed: Other research has shown promise in targeting genetic pathways in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Delaney, Joe R — Medical University of South Carolina
- Study coordinator: Delaney, Joe R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.