Investigating how changes in RNA processing may contribute to diabetes
Alternative polyadenylation as a novel mechanism for diabetes
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11097364
This study is looking at how certain genes might affect the risk of developing type 2 diabetes in people who are obese, focusing on a process that helps control gene activity, and the goal is to find new ways to prevent or treat diabetes based on individual genetic differences.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11097364 on ClinicalTrials.gov |
What this research studies
This research explores the genetic factors that influence the development of type 2 diabetes (T2D) in obese individuals, focusing on a specific RNA processing mechanism called alternative polyadenylation. By analyzing genetic variants associated with T2D, the study aims to understand how these variants affect the length of non-coding RNA sequences, which in turn may impact gene expression and insulin production. Patients may benefit from insights that could lead to new prevention or treatment strategies for diabetes based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research include obese individuals who are at risk of developing type 2 diabetes, particularly those with a family history of the condition.
Not a fit: Patients who are not obese or do not have a genetic predisposition to type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized approaches for preventing or managing type 2 diabetes in at-risk individuals.
How similar studies have performed: Other research has shown promise in understanding genetic factors in diabetes, but the specific approach of targeting alternative polyadenylation is relatively novel.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, QIN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: YANG, QIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus