Investigating how changes in histone methylation affect genome stability.
Altering the chromostasis and genome stability by modulating histone methylation
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10866494
This study is looking at how changes in certain proteins that help organize our DNA can affect how our genes work and how our cells repair themselves, with the hope of finding new ways to understand and treat breast cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10866494 on ClinicalTrials.gov |
What this research studies
This research explores the concept of chromostasis, which refers to maintaining a stable chromatin environment that prevents genome instability. It focuses on how modifications to histones, which are proteins that help package DNA, can influence gene expression and DNA repair processes. By studying specific mutations in histone proteins, the research aims to uncover the interactions between different histone modifications and their impact on cellular functions, particularly in relation to cancer development. Patients may benefit from insights gained about how these mechanisms contribute to diseases like breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast cancer or those diagnosed with breast cancer who may have underlying genetic factors related to histone modifications.
Not a fit: Patients without a genetic predisposition to breast cancer or those not affected by genome stability issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with genome instability.
How similar studies have performed: Other research has shown promising results in understanding the role of histone modifications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOREY, LLUIS — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: MOREY, LLUIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer 1 Gene, Breast Cancer 1 Gene Product, Breast Cancer Type 1 Susceptibility Gene