Investigating how changes in histone acetylation affect Parkinson's disease
Dysregulation of Histone Acetylation in Parkinson's Disease
This study is looking at how changes in a process called histone acetylation might lead to the loss of nerve cells in Parkinson's disease, with the hope that understanding this could help find new ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10855703 on NIH RePORTER |
What this research studies
This research explores the role of histone acetylation in the development of Parkinson's disease and related conditions. By using a specialized platform that mimics disease-relevant neuronal cells, the researchers aim to understand how dysregulated histone acetylation contributes to neuronal cell loss. The study combines advanced techniques like proteomics and CRISPR screening to identify factors that influence histone acetylation and its impact on gene expression. Insights gained from this research could lead to new therapeutic approaches for managing Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or related neurodegenerative disorders.
Not a fit: Patients with non-neurodegenerative conditions or those not diagnosed with Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of histone modifications in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Soldner, Frank — Albert Einstein College of Medicine
- Study coordinator: Soldner, Frank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.