Investigating how changes in histone acetylation affect Parkinson's disease
Official title: Dysregulation of Histone Acetylation in Parkinson's Disease
Funded at Albert Einstein College of Medicine · NIH-10855703 · Data updated 2026-11-12
This study is looking at how changes in a process called histone acetylation might lead to the loss of nerve cells in Parkinson's disease, with the hope that understanding this could help find new ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 11, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $624,231 |
| NIH project number | 1R56NS128015-01A1 |
| Project ID | NIH-10855703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease or related neurodegenerative disorders.
✕Less likely to help
Patients with non-neurodegenerative conditions or those not diagnosed with Parkinson's disease may not benefit from this research.
What this research studies
This research explores the role of histone acetylation in the development of Parkinson's disease and related conditions. By using a specialized platform that mimics disease-relevant neuronal cells, the researchers aim to understand how dysregulated histone acetylation contributes to neuronal cell loss. The study combines advanced techniques like proteomics and CRISPR screening to identify factors that influence histone acetylation and its impact on gene expression. Insights gained from this research could lead to new therapeutic approaches for managing Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Parkinson's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of histone modifications in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Soldner, Frank — Albert Einstein College of Medicine
- Study coordinator: Soldner, Frank
Related research
Other NIH-funded projects on the same topics.
-
Gut-brain clues in Parkinson’s disease: supplement to a large registry
A plant-wide supplement to an NIH program will enroll people with Parkinson’s, with and without GI symptoms, plus healthy controls, to study how gut function, brain signals, and sleep rhythms relate to Parkinson’s symptoms.
-
Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
-
Gut-brain communication in Parkinson’s disease for better symptoms and daily life
This project enrolls people with Parkinson’s disease and healthy controls to build a big registry and study how gut function, brain signals, sleep, and circadian rhythms relate to PD symptoms.
-
Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression
A multi-year study will look at gut bacteria and related markers in people with Parkinson’s disease to understand how the gut-brain connection may influence symptoms and progression.
-
Gut-Brain Axis in Parkinson’s Disease: biomarkers and procedures to track progression
A patient-focused program to study how gut health and the brain interact in Parkinson’s disease using biomarkers and clinical procedures.
-
Understanding posture and movement in Parkinson’s patients to reduce falls
A study using wearable sensors to track real-world balance and movement in people with Parkinson’s disease to help prevent falls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.