Investigating how changes in gut bacteria relate to colorectal cancer development after APC gene mutation
Official title: Defining the changing microbiome composition and host-microbe mechanistic effects following Apc inactivation during colorectal cancer pathogenesis
Funded at Johns Hopkins University · NIH-10913354 · Data updated 2026-11-12
This study is looking at how changes in a specific gene related to colorectal cancer can affect the bacteria in the gut, using mice to see if these changes might play a role in cancer development.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 16, 2023 |
| Project end | September 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31CA284760-02 |
| Project ID | NIH-10913354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of colorectal cancer or those diagnosed with conditions related to APC mutations.
✕Less likely to help
Patients without any genetic predisposition to colorectal cancer or those who do not have any gastrointestinal issues may not benefit from this research.
What this research studies
This research focuses on understanding how mutations in the APC gene, which is crucial for preventing colorectal cancer, affect the composition of gut bacteria. By using a mouse model, the study will explore how these mutations lead to changes in the microbiome and whether these changes contribute to the progression of cancer. The researchers aim to identify the timing and mechanisms of these microbiome alterations, which could provide insights into the relationship between gut health and cancer development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colorectal cancer by targeting microbiome changes.
How similar studies have gone: Previous research has shown that alterations in the gut microbiome can influence cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Dzierozynski, Lindsey — Johns Hopkins University
- Study coordinator: Dzierozynski, Lindsey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.