Investigating how changes in gene expression contribute to heart tissue scarring in pulmonary hypertension
Alternative polyadenylation in Right Ventricular Fibrosis
['FUNDING_OTHER'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-11192961
This study is looking into how certain changes in our genes might cause scarring in the heart's right side for people with pulmonary hypertension, and it hopes to find new ways to help treat this serious condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11192961 on ClinicalTrials.gov |
What this research studies
This research explores the molecular mechanisms behind right ventricular fibrosis, a serious condition associated with pulmonary hypertension. It focuses on a process called alternative polyadenylation, which affects how genes are expressed and can lead to excessive production of proteins that contribute to heart tissue scarring. By studying the role of a specific protein, CPSF6, and its interaction with reactive aldehydes, the research aims to uncover new insights into the causes of right ventricular failure. The findings could lead to the development of targeted therapies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pulmonary hypertension who are experiencing right ventricular failure.
Not a fit: Patients with pulmonary hypertension who do not exhibit signs of right ventricular failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the underlying causes of right ventricular fibrosis, improving outcomes for patients with pulmonary hypertension.
How similar studies have performed: Previous research has shown promising results in understanding the role of gene expression in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AMIRTHALINGAM THANDAVARAYAN, RAJARAJAN — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: AMIRTHALINGAM THANDAVARAYAN, RAJARAJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiovascular Diseases