Investigating how changes in epigenetic regulators affect development and disease
Single-cell epigenomic phenotyping of IMPC-generated mouse lines lacking chromatin regulators
This study is looking at how certain genes that control other genes affect development and diseases in humans, using special mice to see what happens when these controls are missing, with the hope of finding better ways to diagnose and treat conditions like birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11098584 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of epigenetic regulators in mammalian development and their connection to various human diseases. By using genetically modified mouse models that lack specific epigenetic regulators, researchers will employ advanced single-cell technologies to analyze how these changes impact gene regulation at a cellular level. The findings aim to provide insights into the mechanisms behind congenital malformations and other diseases influenced by epigenetic factors, potentially leading to improved diagnostics and treatments tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital malformations or diseases suspected to be influenced by epigenetic factors.
Not a fit: Patients with conditions unrelated to epigenetic regulation or those not experiencing congenital malformations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital malformations and diseases linked to epigenetic changes.
How similar studies have performed: Other research has shown success in using similar approaches to investigate the role of epigenetics in disease, indicating a promising avenue for further exploration.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Gorkin, David Uscher — Emory University
- Study coordinator: Gorkin, David Uscher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.