Investigating how changes in chromosome numbers affect cancer growth in fruit flies.
Official title: Polyploidy and Sex Dimorphism in a Drosophila Tumor Model
Funded at Tulane University of Louisiana · NIH-10999201 · Data updated 2026-11-12
This study is looking at how changes in chromosome numbers might lead to cancer by using fruit flies, and it aims to help us understand what drives tumor growth, which could eventually lead to new treatments for cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $341,248 |
| NIH project number | 1R01CA287524-01A1 |
| Project ID | NIH-10999201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with high-grade cancers that exhibit chromosomal abnormalities.
✕Less likely to help
Patients with cancers that do not show significant chromosomal variations may not benefit from this research.
What this research studies
This research explores the role of chromosome number variations, such as polyploidy and aneuploidy, in cancer development using a fruit fly model. By studying tumors driven by specific genetic changes, the researchers aim to understand how these chromosomal alterations contribute to tumor growth and progression. The project employs advanced techniques like RNA sequencing to analyze gene expression and identify key factors involved in tumor behavior. The findings could provide insights into the mechanisms of cancer and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer treatment by targeting the underlying genetic mechanisms of tumor growth.
How similar studies have gone: Previous studies have shown that understanding chromosomal variations in cancer can lead to significant advancements in treatment strategies, indicating a promising avenue for this research.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Deng, Wu-Min — Tulane University of Louisiana
- Study coordinator: Deng, Wu-Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.