Investigating how changes in cell membrane voltage affect cancer stem cells
A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state
['FUNDING_OTHER'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-11059076
This study is looking at how the electrical activity in cancer cells affects their growth and development, with the goal of finding better ways to treat cancer by understanding these changes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11059076 on ClinicalTrials.gov |
What this research studies
This research explores the role of membrane voltage in regulating cancer stem cell behavior, particularly how it influences their differentiation and proliferation. By integrating advanced sensors that can measure membrane voltage and cell cycle states, the study aims to develop a high-throughput platform for assessing these changes in cancer cells. This innovative approach seeks to overcome current limitations in measuring membrane voltage, potentially leading to new therapeutic strategies against cancer. Patients may benefit from insights gained about how to target cancer stem cells more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer, particularly those with aggressive or treatment-resistant forms.
Not a fit: Patients with non-cancerous conditions or those whose cancer has already been effectively treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target cancer stem cells, potentially improving outcomes for cancer patients.
How similar studies have performed: While the concept of targeting membrane voltage in cancer therapy is relatively novel, similar approaches in other areas of cancer research have shown promise.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSTOMILY, ROBERT C — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: ROSTOMILY, ROBERT C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, cancer cell, cancer metastasis, Cancer Patient, cancer progenitor