Investigating how changes in cell genetics affect cancer development
Combining modeling and experiments to study the evolution of cells with altered ploidy
This study is looking at how having the wrong number of chromosomes in cells can affect cancer growth, and it aims to help patients by uncovering the genetic reasons behind tumor development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10754514 on NIH RePORTER |
What this research studies
This research explores the role of aneuploidy, a condition where cells have an abnormal number of chromosomes, in cancer progression. It focuses on how cells can double their genome and the implications this has for tumor growth and stability. By combining experimental techniques with modeling, the study aims to understand the mechanisms behind chromosome missegregation during cell division and how this contributes to cancer. Patients may benefit from insights gained into the genetic factors that drive tumor development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that exhibit aneuploidy or chromosomal instability.
Not a fit: Patients with cancers that do not involve aneuploidy or chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with aneuploidy.
How similar studies have performed: Previous research has shown that understanding the genetic basis of aneuploidy can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Cimini, Daniela — Virginia Polytechnic Inst and St Univ
- Study coordinator: Cimini, Daniela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.