Investigating how changes in cardiolipin affect Alzheimer's disease
Cardiolipin Remodeling in Alzheimer’s Disease
This study is looking at how a special fat in our cells, called cardiolipin, might play a role in Alzheimer's disease as we age, and it’s trying to find ways to help keep our brains healthy by focusing on a specific enzyme that affects this fat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11076323 on NIH RePORTER |
What this research studies
This research explores the role of cardiolipin, a crucial phospholipid in mitochondria, in the development of Alzheimer's disease (AD). It focuses on how aging leads to bioenergetic dysfunction in the brain, which is linked to AD. The study examines a specific enzyme, ALCAT1, that alters cardiolipin composition and contributes to mitochondrial dysfunction. By understanding these mechanisms, the research aims to identify potential therapeutic targets for mitigating the effects of aging on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or have early signs of Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction in neurodegenerative diseases, suggesting that this approach may be effective.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Shi, Yuguang — University of Texas Hlth Science Center
- Study coordinator: Shi, Yuguang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.