Investigating how changes in brain metabolism affect aging and Alzheimer's disease
Alterations in neuronal metabolic pathways contribute to human cognitive aging and are exacerbated in Alzheimer's disease
This study is looking at how aging affects brain cells and how these changes are even more pronounced in Alzheimer's disease, using brain cells from patients to find ways to help improve thinking and memory in older adults.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-10894920 on NIH RePORTER |
What this research studies
This research focuses on understanding the metabolic changes in neurons that occur with aging and how these changes are intensified in Alzheimer's disease. By using induced neurons derived from patients, the study aims to differentiate between normal aging processes and those associated with Alzheimer's. The researchers will employ various experimental techniques to analyze these metabolic pathways, which could lead to new therapeutic strategies for Alzheimer's. The goal is to identify specific alterations that could be targeted to improve cognitive health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those with a diagnosis of Alzheimer's disease or cognitive impairment.
Not a fit: Patients under the age of 65 or those without cognitive impairment or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or alter the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in understanding metabolic pathways in aging and Alzheimer's, but this specific approach using induced neurons is relatively novel.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Jones, Jeffrey Ray — Salk Institute for Biological Studies
- Study coordinator: Jones, Jeffrey Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.