Investigating how changes in brain connections affect Down syndrome
Human Embryonic Stem Cell Models for Studying Mechanisms Underlying Changes In Inhibitory Synapses in Down Syndrome
This study is looking at how certain genes in people with Down syndrome affect brain connections that help control brain activity, with the hope of finding new ways to improve thinking and memory for those with the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10950411 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind changes in inhibitory synapses in individuals with Down syndrome, a condition caused by an extra copy of chromosome 21. By using human embryonic stem cell models, the researchers aim to explore how these genetic factors contribute to neurological issues such as intellectual disability and Alzheimer's disease. The study will investigate the role of specific genes and their impact on the GABAergic system, which is crucial for brain function. Through this approach, the research seeks to uncover potential targets for new treatments that could improve cognitive outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Down syndrome, particularly those experiencing cognitive challenges or related neurological conditions.
Not a fit: Patients without Down syndrome or those who do not exhibit cognitive impairments related to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance cognitive function and reduce the risk of Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding GABAergic dysregulation in animal models, suggesting that this approach may yield valuable insights for human conditions.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Smith, Gary Daniel — University of Michigan at Ann Arbor
- Study coordinator: Smith, Gary Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.