Investigating how changes in blood pressure may contribute to dementia.

Who could benefit from this research

What this research studies

This research explores the connection between blood pressure variability and the development of Alzheimer's disease and related dementias. By analyzing data from multiple cohort studies in the US and Europe, the project aims to quantify how fluctuations in blood pressure over time may influence dementia risk. The study will also investigate the biological mechanisms that link blood pressure changes to dementia, potentially leading to new prevention strategies. Patients may be involved in providing data or participating in assessments related to their blood pressure and cognitive health.

Why it matters

Where this research is happening

• Harvard School of Public Health
  Boston, United States Active

Researchers

• Principal investigator: Ma, Yuan — Harvard School of Public Health
• Study coordinator: Ma, Yuan

Related research

Other NIH-funded projects on the same topics.

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  NIH research University of California, San Francisco · San Francisco, United States · NIH-11197583

• Investigating the link between hypertension and Alzheimer's risk in US veterans

  This study is looking at how managing high blood pressure might affect the chances of U.S. veterans developing Alzheimer's and other types of dementia, especially for those who might be at greater risk due to their background or military experiences.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10806472

• Investigating how DNA damage and repair mechanisms are altered in ALS and frontotemporal dementia.

  This study is looking at how problems with DNA repair might contribute to conditions like ALS and frontotemporal dementia, and it’s testing ways to fix these issues in cells from patients to help develop new treatments.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-9980670

• Actions to Decrease Disparities in Blood Pressure Control for Blacks

  Aiming to help Black patients manage high blood pressure by using nurses, community health workers, and home monitoring in real-world clinics.

  NIH research New York University School of Medicine · New York, United States · NIH-11644510

• Synthetic protein mimetics to treat Lewy Body Dementia

  A new therapeutic approach using engineered protein-like molecules to block the harmful protein clumps that cause Lewy Body Dementia.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-11641877

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.