Investigating how changes in a specific protein in brain cells affect memory and cognitive function.
Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function
This study is looking at how a protein called TDP-43 affects brain cells, especially those that support neurons, to see how problems with this protein might lead to memory loss and thinking difficulties in people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10609968 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called TDP-43 in brain cells, particularly astrocytes, and how its dysregulation may lead to cognitive impairments associated with Alzheimer's disease and other neurodegenerative conditions. By examining the interactions between astrocytes and neurons, the study aims to uncover the mechanisms that contribute to memory loss and cognitive decline. The research utilizes animal models and human cases to explore these relationships and their implications for brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals and patients diagnosed with Alzheimer's disease or other neurodegenerative conditions.
Not a fit: Patients with cognitive impairments not related to neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for cognitive impairments in patients with Alzheimer's disease and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Orr, Anna Goldshmidt — Weill Medical Coll of Cornell Univ
- Study coordinator: Orr, Anna Goldshmidt
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.