Investigating how changes in a specific protein affect brain function in people with HIV
The role of TFAM alterations in HIV- and ART-induced mitochondrial dysfunction in the brain
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10984471
This study is looking at how changes in a protein called TFAM affect brain health in people with HIV, especially those on treatment, to find ways to help improve their neurological issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10984471 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the impact of alterations in the TFAM protein on mitochondrial dysfunction in the brains of individuals living with HIV. It aims to explore how these changes contribute to neurological issues, particularly in those receiving antiretroviral therapy (ART). By examining the role of reactive astroglia and their metabolic functions, the study seeks to identify potential therapeutic targets to improve brain health in HIV patients. The approach involves analyzing brain tissue and cellular responses to better understand the underlying mechanisms of HIV-associated neurocognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience neurological symptoms, particularly those on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those without neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate neurological dysfunction in people living with HIV.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FIELDS, JEREL ADAM — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: FIELDS, JEREL ADAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus