Investigating how changes in a specific heart protein contribute to heart failure
Dynamic changes of the Nav1.5 interactome and contributions to heart failure
This study is looking at a special protein in the heart that helps start heartbeats, to learn how problems with it can cause heart issues like arrhythmias and heart failure, with the hope of finding new ways to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10892890 on NIH RePORTER |
What this research studies
This research focuses on the NaV1.5 voltage-gated sodium channel, which plays a crucial role in initiating heartbeats. It aims to understand how abnormalities in this channel can lead to various heart conditions, including arrhythmias and dilated cardiomyopathy. By employing advanced techniques to explore the interactions of NaV1.5 with other proteins, the study seeks to uncover the mechanisms behind heart failure and arrhythmias. Patients may benefit from insights that could lead to new treatments or preventive strategies for heart-related issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of cardiac arrhythmias or dilated cardiomyopathy.
Not a fit: Patients with heart conditions unrelated to NaV1.5 dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with heart failure and arrhythmias.
How similar studies have performed: Previous research has shown promise in understanding cardiac arrhythmias through similar approaches, indicating potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Pitt, Geoffrey S — Weill Medical Coll of Cornell Univ
- Study coordinator: Pitt, Geoffrey S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.