Investigating how changes in a specific fat molecule affect brain injury in newborns after oxygen deprivation.
Official title: Evaluation of Mitochondrial Cardiolipin Modification in Neonatal Hypoxia/Ischemia Encephalopathy
Funded at University of Michigan at Ann Arbor · NIH-11097258 · Data updated 2026-11-12
This study is looking at how changes in a specific fat in brain cells might affect brain injuries in newborns who don't get enough oxygen, and it hopes to find ways to better protect their brains during these tough times.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $43,995 |
| NIH project number | 5F31NS129326-03 |
| Project ID | NIH-11097258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns who have experienced hypoxia or ischemia during birth.
✕Less likely to help
Patients who have not experienced any form of brain injury or oxygen deprivation may not benefit from this research.
What this research studies
This research focuses on understanding the impact of mitochondrial cardiolipin modification on brain injuries caused by hypoxia/ischemia in newborns. The study aims to explore how reestablishing blood flow and oxygen delivery can lead to oxidative stress and damage in the brain. Using advanced techniques like cyclic ion mobility spectrometry mass spectrometry, researchers will analyze the structural changes in cardiolipin and its role in brain injury. The findings could provide insights into potential therapeutic targets for protecting the infant brain during critical periods of oxygen deprivation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating brain damage in newborns suffering from oxygen deprivation.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function and oxidative stress in brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Emaus, Katlynn Joy — University of Michigan at Ann Arbor
- Study coordinator: Emaus, Katlynn Joy
Related research
Other NIH-funded projects on the same topics.
-
Using MRI to measure brain oxygen levels as an early sign of small vessel disease in the brain
This study is looking at how measuring oxygen levels in the brain with MRI can help spot early signs of small vessel disease, which is linked to memory problems and dementia, especially Alzheimer's, so if you're at risk due to age or high blood pressure, you might be able to participate in MRI scans to learn more about
-
HIF-driven ways to repair damaged lungs in IPF
A doctor-researcher is testing how low-oxygen signals (HIF) could help restore healthy lung tissue in people with IPF.
-
Neonatal Brain Injury Protection with New Purine Compounds
A new medication approach using purine derivatives is being studied to protect newborn brains from injury caused by limited blood flow and oxygen during birth.
-
Aldo-keto reductase (AKR) helps brain BH4 levels after injury
This grant tests whether brain AKR enzymes can boost BH4 levels and support better brain function after hypoxia-ischemia-related injury.
-
Dual-hypoxia and proliferation PET biomarker for recurrent glioblastoma
A study using a special PET imaging approach to map oxygen-poor areas and cell growth in recurrent brain tumors to guide treatment decisions.
-
How low oxygen and genetic tweaks may repair mitochondrial problems linked to Alzheimer’s and other disorders
A Johns Hopkins-style? (Note: institution specified later) patient-facing overview: researchers will study tiny cell power stations in mitochondria to see if low-oxygen conditions and specific genetic changes can fix problems associated with Alzheimer's disease and related dementias.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.