Investigating how changes in a specific fat molecule affect brain injury in newborns after oxygen deprivation.
Evaluation of Mitochondrial Cardiolipin Modification in Neonatal Hypoxia/Ischemia Encephalopathy
This study is looking at how changes in a specific fat in brain cells might affect brain injuries in newborns who don't get enough oxygen, and it hopes to find ways to better protect their brains during these tough times.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11097258 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of mitochondrial cardiolipin modification on brain injuries caused by hypoxia/ischemia in newborns. The study aims to explore how reestablishing blood flow and oxygen delivery can lead to oxidative stress and damage in the brain. Using advanced techniques like cyclic ion mobility spectrometry mass spectrometry, researchers will analyze the structural changes in cardiolipin and its role in brain injury. The findings could provide insights into potential therapeutic targets for protecting the infant brain during critical periods of oxygen deprivation.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns who have experienced hypoxia or ischemia during birth.
Not a fit: Patients who have not experienced any form of brain injury or oxygen deprivation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating brain damage in newborns suffering from oxygen deprivation.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and oxidative stress in brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Emaus, Katlynn Joy — University of Michigan at Ann Arbor
- Study coordinator: Emaus, Katlynn Joy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.