Investigating how changes in a protein linked to Alzheimer's disease affect its development
Official title: Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesis
Funded at University of Virginia · NIH-11080997 · Data updated 2026-11-12
This study is looking at how a protein called APOE changes in the brain and how these changes might affect the risk of developing Alzheimer's disease, with the hope of finding new ways to help people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | February 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $538,880 |
| NIH project number | 5R01AG072505-05 |
| Project ID | NIH-11080997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with different APOE genotypes.
✕Less likely to help
Patients with forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of apolipoprotein E (APOE) glycosylation in the development of Alzheimer's disease. By analyzing how different forms of APOE interact with other molecules in the brain, the study aims to uncover the mechanisms that increase or decrease Alzheimer's risk. The research will utilize advanced techniques to examine APOE from various sources, including cells derived from induced pluripotent stem cells, to determine how glycosylation affects its function. This could lead to new insights into Alzheimer's pathology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOE in Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Flowers, Sarah Ann — University of Virginia
- Study coordinator: Flowers, Sarah Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.