Investigating how certain viruses may influence the development of Alzheimer's disease.
Viral IncRNAs Regulate Host Genomic Transcriptional Programs Associated with Sporadic Alzheimer's Disease
This study is looking at how certain viral infections, like the ones that cause cold sores and COVID-19, might be linked to the development of Alzheimer's disease, and it will analyze brain samples to understand how these viruses could affect brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10885091 on NIH RePORTER |
What this research studies
This research explores the relationship between viral infections, particularly Herpes Simplex Virus 1 and SARS-CoV-2, and their potential role in the development of sporadic Alzheimer's disease. By utilizing advanced genomic technologies, the study aims to analyze how viral gene products affect gene expression in brain cells, which may contribute to neurodegenerative processes. Patients' brain samples will be examined to identify specific transcriptional changes associated with Alzheimer's, providing insights into the underlying mechanisms of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with sporadic Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with early-onset Alzheimer's disease or those without any viral infection history may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting viral influences on Alzheimer's disease progression.
How similar studies have performed: Previous research has indicated a link between viral infections and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Rosenfeld, Michael G — University of California, San Diego
- Study coordinator: Rosenfeld, Michael G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.