Investigating how certain viral proteins affect cancer development
Official title: Roles of p53-Regulated Pro-Survival Signals in Carcinogenesis by HTLV-1 and High-Risk Subtype HPVs
Funded at Southern Methodist University · NIH-10572142 · Data updated 2026-11-12
This study is looking at how certain proteins from the HTLV-1 virus and high-risk HPVs might help cause aggressive cancers, like adult T-cell leukemia, and aims to find new ways to treat these cancers by understanding how these viruses affect our cells.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Methodist University NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 13, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $445,500 |
| NIH project number | 1R15CA267892-01A1 |
| Project ID | NIH-10572142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with adult T-cell leukemia/lymphoma or cervical cancer associated with high-risk HPVs.
✕Less likely to help
Patients with cancers unrelated to HTLV-1 or high-risk HPVs may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins from the human T-cell leukemia virus type-1 (HTLV-1) and high-risk human papillomaviruses (HPVs) in the development of aggressive cancers like adult T-cell leukemia/lymphoma. The researchers are using advanced techniques, including CRISPR, to explore how these viral proteins interact with cellular mechanisms that regulate cell death and cancer progression. By studying these interactions, the research aims to uncover new insights into how these viruses contribute to cancer and potentially identify new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with cancers associated with HTLV-1 and high-risk HPVs.
How similar studies have gone: Previous research has shown promising results in understanding viral contributions to cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Southern Methodist University
Dallas, United States Active
Researchers
- Principal investigator: Harrod, Robert L. — Southern Methodist University
- Study coordinator: Harrod, Robert L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.