Investigating how certain vesicles affect blood clotting in sickle cell disease
Official title: CD39-carrying extracellular vesicles regulate pulmonary thrombosis in Sickle Cell Disease
Funded at Versiti Wisconsin, INC. · NIH-11002819 · Data updated 2026-11-12
This study is looking at how tiny particles in the blood, called extracellular vesicles, might affect blood clots in the lungs of people with sickle cell disease, with the goal of finding better ways to diagnose and treat this serious problem.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $778,418 |
| NIH project number | 7R01HL166345-02 |
| Project ID | NIH-11002819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sickle cell disease, particularly those who have experienced respiratory failure due to pulmonary thrombosis.
✕Less likely to help
Patients without sickle cell disease or those who do not experience pulmonary complications may not benefit from this research.
What this research studies
This research focuses on understanding how extracellular vesicles carrying CD39 can influence pulmonary thrombosis in patients with sickle cell disease (SCD). The study aims to identify the molecular and genetic mechanisms that lead to blood clots in the lungs, which can cause severe respiratory issues. By examining the role of adenosine diphosphate (ADP) in platelet activation and its relationship with pulmonary thrombosis, the researchers hope to develop targeted diagnostic and therapeutic strategies for patients at risk. This approach could lead to more effective treatments for those suffering from this serious complication of SCD.
Why it matters
Potential benefit: If successful, this research could lead to new preventive therapies for pulmonary thrombosis in sickle cell disease patients.
How similar studies have gone: While the specific approach of targeting CD39 in extracellular vesicles is novel, previous studies have shown promise in understanding and treating thrombotic events in sickle cell disease.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Sundd, Prithu — Versiti Wisconsin, INC.
- Study coordinator: Sundd, Prithu
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.