Investigating how certain toxic chemicals affect lung function
Official title: Lipid and metabolic mechanisms responsible for phosgene and phosphorus trichloride exposure toxicity
Funded at Saint Louis University · NIH-10907734 · Data updated 2026-11-12
This study is looking into how certain harmful chemicals can hurt your lungs and cause serious breathing problems, with the goal of finding better ways to treat those injuries for people who might be affected by accidents or chemical exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $303,000 |
| NIH project number | 5R01ES035365-02 |
| Project ID | NIH-10907734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to phosgene or phosphorus trichloride, particularly in industrial or military settings.
✕Less likely to help
Patients who have not been exposed to these specific chemicals or who have unrelated lung conditions may not benefit from this research.
What this research studies
This research focuses on understanding the harmful effects of phosgene and phosphorus trichloride, which can occur due to industrial accidents or chemical warfare. It aims to uncover the biological mechanisms that lead to acute lung injuries, such as apnea and pulmonary edema, following exposure to these chemicals. By analyzing lipid and metabolic changes in lung cells, the study seeks to identify how these toxic agents disrupt normal lung function. Patients may benefit from insights gained through extensive analyses that could lead to improved treatments for lung injuries caused by these exposures.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for lung injuries caused by toxic chemical exposures.
How similar studies have gone: While the specific mechanisms of phosgene and phosphorus trichloride toxicity are not well-studied, similar research on other chemical exposures has shown promising results in understanding lung injury mechanisms.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Ford, David a. — Saint Louis University
- Study coordinator: Ford, David a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.