Investigating how certain T cells respond to bacterial and mitochondrial lipids
Official title: Activation of human CD1a-restricted T cells by bacterial and mitochondrial lipids
Funded at Columbia University Health Sciences · NIH-11138175 · Data updated 2026-11-12
This study is looking at a special kind of immune cell that helps the body respond to certain fats found in both bacteria and our own cells, to see how these cells might help control immune reactions without causing inflammation, which could be important for understanding conditions like autoimmune diseases and skin allergies.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 17, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $239,348 |
| NIH project number | 1R21AI185955-01A1 |
| Project ID | NIH-11138175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases or allergic dermatitis who may benefit from improved understanding and treatment options.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by allergic reactions may not receive direct benefits from this research.
What this research studies
This research focuses on a specific type of T cell that responds to lipid antigens, particularly phosphatidylglycerol (PG), which is found in both bacteria and human mitochondria. The study aims to understand the role of CD1a-restricted T cells in the immune system, particularly how they may regulate immune responses rather than provoke inflammation. By examining these lipid-specific T cells, the research seeks to uncover their potential functions and implications for conditions like autoimmune diseases and allergic dermatitis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into immune regulation and potential therapeutic strategies for autoimmune and allergic conditions.
How similar studies have gone: While the investigation of lipid-specific T cells is relatively novel, similar research has shown promise in understanding immune responses, suggesting potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: De Jong, Annemieke — Columbia University Health Sciences
- Study coordinator: De Jong, Annemieke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.