Investigating how certain small RNAs affect T-cell leukemia treatment
Official title: Exploring microRNA degradation in T-cell acute lymphoblastic leukemia
Funded at University of Florida · NIH-11059702 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNAs affect treatment for T-cell acute lymphoblastic leukemia (T-ALL) and aims to find new ways to make chemotherapy work better for patients by understanding how a specific mRNA interacts with these microRNAs when treated with a common drug.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $81,624 |
| NIH project number | 3R01CA282812-02S1 |
| Project ID | NIH-11059702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with T-cell acute lymphoblastic leukemia who are undergoing chemotherapy.
✕Less likely to help
Patients with other types of leukemia or those not receiving chemotherapy may not benefit from this research.
What this research studies
This research focuses on understanding the role of microRNAs in T-cell acute lymphoblastic leukemia (T-ALL) and how their degradation can influence cancer treatment. The study examines how a specific mRNA, BIM, can degrade two microRNAs (miR-221/222) when T-ALL cells are treated with a common chemotherapy drug, dexamethasone. By exploring this unexpected interaction, the research aims to develop new strategies for enhancing the effectiveness of chemotherapy in T-ALL patients. Additionally, the project will create a method to identify other mRNAs that may also induce microRNA degradation in T-ALL samples.
Why it matters
Potential benefit: If successful, this research could lead to improved chemotherapy outcomes for patients with T-cell acute lymphoblastic leukemia.
How similar studies have gone: While the specific approach of mRNA-induced microRNA degradation is novel, similar research has shown promise in understanding gene regulation in cancer.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Xie, Mingyi — University of Florida
- Study coordinator: Xie, Mingyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.