Investigating how certain signals affect heart muscle growth and remodeling
MDM2-HIF signaling in pathological ventricular remodeling
This study is looking into how and why the heart muscle thickens in people with a condition called left ventricular hypertrophy, using mice with similar genetic traits to help us understand what happens in the heart and how it affects its function over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11074582 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind pathological left ventricular hypertrophy (LVH), a condition where the heart muscle thickens and can lead to heart failure. By using mouse models with genetic mutations similar to those found in humans, the study aims to uncover how both heart muscle cells and their surrounding environment contribute to this condition. The researchers will explore various cellular signaling pathways that influence heart muscle growth and the impact of these changes on heart function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic predispositions to heart conditions, particularly those experiencing symptoms of heart failure or left ventricular hypertrophy.
Not a fit: Patients with heart conditions unrelated to left ventricular hypertrophy or those who do not have genetic factors contributing to heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse heart muscle thickening, improving outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding cardiac remodeling through similar genetic and cellular signaling approaches, indicating potential for success in this study.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Becker, Jason — University of Pittsburgh at Pittsburgh
- Study coordinator: Becker, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.