Investigating how certain RNA molecules help cells manage stress
Official title: The Nucleolar Detention Center: A Hub of Long Noncoding RNA that Imprison Proteins during Stress
Funded at University of Miami School of Medicine · NIH-11053346 · Data updated 2026-11-12
This study is looking at how certain tiny RNA molecules help cells handle stress, which is important for understanding diseases like cancer and neurological disorders, and it could lead to new ways to improve treatments by showing how stress affects these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $383,750 |
| NIH project number | 5R35GM149221-03 |
| Project ID | NIH-11053346 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cancer or neurological disorders who are affected by cellular stress responses.
✕Less likely to help
Patients with conditions unrelated to cellular stress mechanisms may not receive direct benefits from this research.
What this research studies
This research explores the role of specific noncoding RNA molecules in helping cells adapt to stress, which is crucial for understanding conditions like cancer and neurological disorders. The team has discovered that these RNA molecules can trigger the formation of unique structures called Amyloid-bodies, which temporarily store proteins during stressful situations. By studying these processes, the research aims to uncover new mechanisms of cellular response to environmental challenges, potentially leading to innovative therapeutic strategies. Patients may benefit from insights gained about how stress impacts disease progression and treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing diseases related to stress responses, such as cancer and neurological disorders.
How similar studies have gone: Other research has shown promising results in understanding cellular stress responses, but the specific focus on Amyloid-bodies represents a novel approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Lee, Stephen — University of Miami School of Medicine
- Study coordinator: Lee, Stephen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.