Investigating how certain RNA molecules affect drug metabolism and liver injury
The role of lncRNAs in P450-mediated drug metabolism and drug-induced liver injury
This study is looking at how certain molecules in our cells, called long non-coding RNAs, help control important enzymes that break down medications in the liver, with the goal of improving how well these drugs work and keeping your liver safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11005703 on NIH RePORTER |
What this research studies
This research focuses on understanding the roles of long non-coding RNAs (lncRNAs) in regulating cytochrome P450 (CYP) enzymes, which are crucial for drug metabolism. By examining specific lncRNAs associated with key transcription factors, the study aims to uncover how these molecules influence the expression of CYP genes and, consequently, the therapeutic outcomes of various medications. The research employs molecular biology techniques to analyze gene expression and histone modifications in liver cells, which could lead to better predictions of drug responses and liver safety.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are prescribed medications that are metabolized by cytochrome P450 enzymes and may be at risk for drug-induced liver injury.
Not a fit: Patients who do not take medications metabolized by cytochrome P450 enzymes or those with pre-existing liver conditions unrelated to drug metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug therapies with fewer adverse effects, particularly related to liver injury.
How similar studies have performed: Previous research has shown promising results in understanding the role of lncRNAs in gene regulation, suggesting that this approach may yield valuable insights into drug metabolism and safety.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Zhong, Xiao-Bo — University of Connecticut Storrs
- Study coordinator: Zhong, Xiao-Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.