Investigating how certain receptors in the immune system respond to cell injury and inflammation.
Official title: Novel histone-binding C-type lectin receptors and their role in sterile inflammation and tissue injury
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10975858 · Data updated 2026-11-12
This study is looking at how certain parts of the immune system react to proteins released when cells get hurt, which could help us understand inflammation and improve treatments for various diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | November 9, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $576,048 |
| NIH project number | 5R01AI173076-03 |
| Project ID | NIH-10975858 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing conditions associated with sterile inflammation, such as stroke or other forms of tissue injury.
✕Less likely to help
Patients with conditions unrelated to immune responses or sterile inflammation may not benefit from this research.
What this research studies
This research explores the role of specific receptors in the immune system that recognize histones, which are released during cell injury. By understanding how these receptors trigger sterile inflammation, the study aims to uncover mechanisms that contribute to various diseases. The researchers have identified a receptor called Clec2d that responds to histones and are looking for additional receptors that may also play a role in human immune responses. This work could lead to new insights into how the immune system reacts to tissue damage and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to tissue injury and inflammation.
How similar studies have gone: Previous research has shown promise in understanding immune responses to cell injury, but the specific receptors being investigated in this study are novel and not yet fully explored in humans.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Rock, Kenneth L — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Rock, Kenneth L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.