Investigating how certain receptors in the body regulate inflammation
Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation
This study is looking at how certain receptors in our cells can affect inflammation, with the goal of finding new treatments that could help people manage conditions related to inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11002266 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms by which G protein-coupled receptors (GPCRs) influence inflammation. The team employs advanced techniques such as cryo-electron microscopy and computational biology to study how these receptors interact with various signaling molecules. By developing new ligands for these receptors, the research aims to identify potential new drugs that can effectively manage inflammatory responses. Patients may benefit from insights gained about how to better control inflammation-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory conditions that may be influenced by GPCR signaling.
Not a fit: Patients with non-inflammatory conditions or those not affected by GPCR-related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for inflammatory diseases.
How similar studies have performed: Previous research has shown success in understanding GPCRs and their roles in inflammation, indicating that this approach is promising.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Zhang, Cheng — University of Pittsburgh at Pittsburgh
- Study coordinator: Zhang, Cheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.