Investigating how certain receptors in brain cells affect signaling and gene activity through primary cilia.
Neuronal Gαi-GPCR targeting to primary cilia and impact on cAMP mediated transcription
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10748277
This study is looking at how tiny structures in brain cells, called cilia, can affect brain signaling and gene activity, which could help us find new ways to treat conditions that impact the brain and mental health.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10748277 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding ciliopathies, which are diseases caused by genetic mutations affecting primary cilia, small organelles on neurons. The study aims to explore how specific receptors located on these cilia can influence neuronal signaling and gene transcription. By identifying the mechanisms that allow these receptors to target cilia selectively, the research could lead to new therapeutic strategies for treating neurological and neuropsychiatric disorders. Patients may benefit from insights gained about how to manipulate these signaling pathways for better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with ciliopathies or related neurological disorders.
Not a fit: Patients without genetic mutations affecting primary cilia or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for various neurological and neuropsychiatric conditions.
How similar studies have performed: Previous research has shown promising results in targeting GPCRs for therapeutic purposes, suggesting potential success for this approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EHRLICH, ALIZA TOBY — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: EHRLICH, ALIZA TOBY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.