Investigating how certain receptors affect kidney fibrosis
BLR&D Merit Review Research Career Scientist (RCS) Award (IK6)
This study is looking at how certain proteins in the kidney help control the balance of tissue building and breaking down, which is important for keeping kidneys healthy, and it aims to find better treatments for kidney problems like fibrosis that can improve how well kidneys work for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11103267 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of extracellular matrix (ECM) receptors in kidney health and disease, particularly how they influence the balance between matrix synthesis and degradation. The principal investigator aims to uncover the mechanisms by which these receptors, such as integrins and discoidin domain receptors, contribute to kidney fibrosis. By studying these processes, the research seeks to develop more effective anti-fibrotic therapies that could improve kidney function and patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic kidney disease or those at risk of developing kidney fibrosis.
Not a fit: Patients with acute kidney injury or those without any signs of kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce kidney fibrosis, improving the quality of life for patients with chronic kidney disease.
How similar studies have performed: Previous research has shown promising results in targeting ECM receptors for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Pozzi, Ambra — Veterans Health Administration
- Study coordinator: Pozzi, Ambra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.