Investigating how certain receptors affect high blood pressure
Inflammatory Nicotinic Acetylcholine Receptors in a Genetic Model of Essential Hypertension
['FUNDING_OTHER'] · IOWA CITY VA MEDICAL CENTER · NIH-10948084
This study is looking at how certain receptors in the body might play a role in high blood pressure, which affects many adults, to help find new ways to treat it in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | IOWA CITY VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10948084 on ClinicalTrials.gov |
What this research studies
This research explores the role of nicotinic acetylcholine receptors in the development of essential hypertension, a condition affecting nearly half of US adults. By studying a genetic model of hypertension, the researchers aim to understand how the nervous and immune systems interact and contribute to high blood pressure. The approach involves identifying specific receptors and their inflammatory responses, which could lead to new therapeutic strategies for managing hypertension. Patients may benefit from insights that could inform future treatments targeting these receptors.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing hypertension or are at risk for developing it.
Not a fit: Patients with hypertension caused by non-genetic factors or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing high blood pressure, improving health outcomes for millions of patients.
How similar studies have performed: Other research has shown promising results in understanding the neuro-immune interactions in hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
IOWA CITY, UNITED STATES
- IOWA CITY VA MEDICAL CENTER — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARWANI, SAILESH — IOWA CITY VA MEDICAL CENTER
- Study coordinator: HARWANI, SAILESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.