Investigating how certain proteins interact to regulate heart and nerve cell activity
KCNE1 as a molecular shield of KV7.1
This study is looking at how certain proteins in your heart and nerves work together, especially focusing on how one protein helps control electrical signals that can affect your heart rhythm and hearing, with the hope of finding new treatments for heart arrhythmias and hearing issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of the Pacific-Stockton NIH-funded |
| Lab location | 1 site (Stockton, United States) |
| Project ID | NIH-10818590 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between specific proteins that play crucial roles in the electrical signaling of heart and nerve cells. It examines how the KV7.1 potassium channel, essential for stopping rapid electrical signals, is influenced by the NaVβ1 protein and protected by KCNE1. By studying these interactions, the research aims to uncover the molecular mechanisms that could lead to heart arrhythmias and hearing disorders. Patients may benefit from insights that could lead to new treatments for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known heart arrhythmias or hearing disorders.
Not a fit: Patients with conditions unrelated to heart or nerve cell electrical signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for heart arrhythmias and hearing disorders.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions in cardiac and neural functions, suggesting potential for success in this area.
Where this research is happening
Stockton, United States
- University of the Pacific-Stockton — Stockton, United States (Active)
Researchers
- Principal investigator: Villalba-Galea, Carlos Alberto — University of the Pacific-Stockton
- Study coordinator: Villalba-Galea, Carlos Alberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.