Investigating how certain proteins interact to regulate cell signaling
Official title: Promoting Receptor Protein Tyrosine Phosphatase Activity by Targeting Transmembrane Domain Interactions
Funded at Lehigh University · NIH-10797721 · Data updated 2026-11-12
This study is looking at special proteins that help control how cells communicate, with the goal of finding new treatments for cancer by understanding how these proteins work together.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | September 20, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $90,505 |
| NIH project number | 3R01GM139998-04S1 |
| Project ID | NIH-10797721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that involve dysregulated receptor tyrosine kinases.
✕Less likely to help
Patients with conditions unrelated to receptor tyrosine kinase signaling may not benefit from this research.
What this research studies
This research focuses on receptor protein tyrosine phosphatases (RPTPs), which are crucial for regulating cell signaling in health and disease. The study aims to understand how the interactions between these proteins affect their activity and how this knowledge can be used to develop new therapies. By examining the molecular mechanisms that control RPTP interactions, the researchers hope to find ways to enhance their function against cancer-related signaling pathways. Patients may benefit from potential new treatments that target these interactions to improve health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers by enhancing the activity of specific proteins involved in cell signaling.
How similar studies have gone: While the specific approach of targeting transmembrane domain interactions is novel, similar research has shown promise in enhancing protein function in other contexts.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Thevenin, Damien — Lehigh University
- Study coordinator: Thevenin, Damien
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.