Investigating how certain proteins influence blood clot formation under stress conditions
Thiol Isomerases and Oxidant Stress in Thrombus Formation
This study is looking at how certain proteins in our bodies might affect blood clotting, especially when there's stress from things like inflammation, and it's aimed at helping people who are at risk for strokes and heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11089521 on NIH RePORTER |
What this research studies
This research explores the role of thiol isomerases, a type of protein, in the formation of blood clots, particularly under oxidative stress conditions. By using genetically modified mice and specific inhibitors, the study aims to understand how these proteins contribute to thrombus formation, which is crucial for conditions like strokes and heart attacks. The researchers will assess how oxidants in the body can modify these proteins and potentially lead to increased clotting. This work builds on previous findings from animal studies and early human trials.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with advanced malignancies who are at high risk for thrombosis.
Not a fit: Patients who do not have conditions associated with increased thrombus formation or those not undergoing treatment for malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent dangerous blood clots in patients, particularly those with cancer or other conditions that increase clotting risk.
How similar studies have performed: Previous studies have shown promising results using PDI inhibitors in reducing cancer-associated thrombosis, indicating a potential for success in this area.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Flaumenhaft, Robert C — Beth Israel Deaconess Medical Center
- Study coordinator: Flaumenhaft, Robert C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.