Investigating how certain proteins influence blood clot formation under stress conditions
Official title: Thiol Isomerases and Oxidant Stress in Thrombus Formation
Funded at Beth Israel Deaconess Medical Center · NIH-11089521 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies might affect blood clotting, especially when there's stress from things like inflammation, and it's aimed at helping people who are at risk for strokes and heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $602,867 |
| NIH project number | 5R01HL167383-02 |
| Project ID | NIH-11089521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with advanced malignancies who are at high risk for thrombosis.
✕Less likely to help
Patients who do not have conditions associated with increased thrombus formation or those not undergoing treatment for malignancies may not benefit from this research.
What this research studies
This research explores the role of thiol isomerases, a type of protein, in the formation of blood clots, particularly under oxidative stress conditions. By using genetically modified mice and specific inhibitors, the study aims to understand how these proteins contribute to thrombus formation, which is crucial for conditions like strokes and heart attacks. The researchers will assess how oxidants in the body can modify these proteins and potentially lead to increased clotting. This work builds on previous findings from animal studies and early human trials.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent dangerous blood clots in patients, particularly those with cancer or other conditions that increase clotting risk.
How similar studies have gone: Previous studies have shown promising results using PDI inhibitors in reducing cancer-associated thrombosis, indicating a potential for success in this area.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Flaumenhaft, Robert C — Beth Israel Deaconess Medical Center
- Study coordinator: Flaumenhaft, Robert C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.