Investigating how certain proteins help repair DNA damage in cancer cells
Official title: The Role of End Synapsis Factors During Telomere Dysfunction
Funded at Salk Institute for Biological Studies · NIH-11221917 · Data updated 2026-11-12
This study is looking at how certain proteins help fix broken DNA in cancer cells, which could lead to better treatments for patients like you by finding new ways to make current therapies work even better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $88,749 |
| NIH project number | 4K00CA284248-02 |
| Project ID | NIH-11221917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing treatment for cancers that involve DNA damage, particularly those receiving therapies that induce double-strand breaks.
✕Less likely to help
Patients with cancers that do not involve DNA double-strand breaks or those not currently receiving treatment may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins involved in the repair of DNA double-strand breaks, which are critical for effective cancer treatment. By examining how these proteins, particularly DNA-PKcs, XLF, and 53BP1, contribute to the repair process, the study aims to identify potential new targets for cancer therapies. The approach includes laboratory experiments to analyze the mechanisms of DNA repair and how they can be influenced by existing cancer treatments. Patients may benefit from insights that could lead to improved cancer therapies that enhance the effectiveness of current treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by improving the way DNA damage is repaired in cancer cells.
How similar studies have gone: Previous research has shown promising results in targeting DNA repair mechanisms in cancer therapy, indicating that this approach has potential for success.
Where this research is happening
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Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Cisneros, Metztli — Salk Institute for Biological Studies
- Study coordinator: Cisneros, Metztli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.