Investigating how certain proteins help in energy transfer within cells
Mechanistic studies of a bifurcating flavoprotein
This study is looking at special proteins in our bodies that help break down fats and how they work, especially a new type that can transfer energy in a unique way, to help us understand how problems with these proteins might lead to certain health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10640091 on NIH RePORTER |
What this research studies
This research focuses on electron-transferring flavoproteins (ETFs), which are essential for various metabolic processes, including the breakdown of fatty acids in humans. The project aims to understand how these proteins function, particularly a newly identified class that uses a process called electron bifurcation to efficiently transfer energy. By studying the kinetics of this process, the research seeks to uncover the mechanisms behind ETF activity and its implications for metabolic disorders. Patients may benefit from insights gained about how defects in these proteins can lead to specific diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders related to fatty acid oxidation or other ETF-related conditions.
Not a fit: Patients with metabolic disorders not associated with electron-transferring flavoprotein defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for metabolic disorders linked to ETF defects.
How similar studies have performed: While the study of electron bifurcation is a relatively novel approach, previous research on electron-transferring flavoproteins has shown promising results in understanding metabolic processes.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Hille, Russ — University of California Riverside
- Study coordinator: Hille, Russ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.